The warning alerts patients about the risk of gadolinium retentionfor months to years after injection. Food and Drug Administration (FDA) issued a requirement for a warning on all gadolinium-based contrast agents, including a new patient Medication Guide that provides educational information that every patient will be asked to read before receiving. However, certain patients may experience some serious side effects, according to. People with normal kidney function usually excrete 90 percent of the injected gadolinium from the body through urine within the first 24 hours. In most cases, having an MRI with contrast dye is safe. Is It Safe to Get an MRI with Contrast Dye? For the most part, injection side effects such as headache, nausea, or vomiting are rare. The aim of our article was to review the current evidence on the usefulness of this new non-invasive diagnostic method in hepatic lesions.Most patients will not experience any sort of sensation when the contrast agent is injected, but some may notice a cold sensation during injection. In these last 2 settings, the complementary use of liver-specific contrast agents can be advantageous. Furthermore, if the lesion has a diameter < 1 cm, diagnosis is usually unreliable. However, in lesions measuring 1-2 cm, establishing the definitive diagnosis is a real challenge, with sensitivity values of 45-65%, but generally with excellent specificity (> 95%). They are more reliable in lesions > 2 cm. In regard to hepatocellular carcinoma, the diagnostic performance of magnetic resonance through the «conventional» protocols and multi-detector computerized tomography consisting of multiphase evaluation with intravenous contrast, largely depends on the size of the lesion. Gadolinium-enhanced magnetic resonance for the evaluation of hepatic lesions is increasingly being used in clinical practice, especially in patients with suspicious focal lesions, whether benign or malignant. El objetivo de este artículo es revisar la evidencia actual de la utilidad de este nuevo método de diagnóstico no invasivo en las lesiones hepáticas. En estos 2 últimos escenarios, el uso complementario de medios de contraste hepatoespecíficos puede ser útil.
Además, si la lesión tiene un diámetro < 1 cm, el diagnóstico es generalmente poco fiable. Sin embargo, para aquellas lesiones de 1-2 cm, el establecimiento de un diagnóstico definitivo es un verdadero reto, con valores de sensibilidad del 45-65%, aunque por lo general con una excelente especificidad (> 95%).
En el caso del carcinoma hepatocelular, el rendimiento diagnóstico de la resonancia magnética a través de protocolos «convencionales» y mediante la tomografía computarizada multidetector, que consiste en la evaluación de múltiples fases con contraste intravenoso, depende en gran medida del tamaño de la lesión, considerándose más certero en lesiones > 2 cm. La resonancia magnética con gadolinio para la evaluación de lesiones hepáticas es un método cada vez más utilizado en la práctica clínica, particularmente para pacientes con lesiones focales sospechosas, ya sean benignas o malignas.
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